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Use of symphytum officinale1/28/2024 ![]() (B) Western blot analysis of samples used in A showing that COX-2 expression can only be found in IL-1β induced samples. Note that both comfrey preparations diminish the IL-1β induced COX-2 activity (black bars), but not the constitutive COX-1 activity (gray bars). Total COX enzymatic activity is depicted compared to non-stimulated, untreated cells. (A) Analysis of total COX-enzymatic activity (COX1/2) comparing unstimulated (UT, gray bars) and IL-1β (5 ng/ml, 90 min) stimulated HUVEC (black bars) which were either left untreated (control) or pretreated (30 min) with comfrey-RE (200 μg/ml), comfrey-OP (20 μg/ml), or TAK inhibitor (5 μM). Relative mRNA levels of E-selectin were normalized to GAPDH and values are depicted as mean fold change compared to non-stimulated cells. (C) Real-time PCR of IL-1β induced (5 ng/ml time points of stimulation as indicated) HUVEC either left untreated (CTRL, circles) or pretreated (30 min) with comfrey-RE (200 μg/ml squares), comfrey-OP (20 μg/ml asterisks) or the TAK1 inhibitor (5Z)-7-oxozeaenol (used as positive control at 5 μM). E-selectin protein levels were analyzed after 2 h. (B) Cell ELISA of IL-1β (5 ng/ml, 90 min) stimulated HUVECs which were either left untreated (CTRL, black bar) or pretreated (30 min) with different doses (either 160, 130, 80, 60 μg/ml) of comfrey-RE (gray bars), comfrey-OP (20, 12, 10, 6 μg/ml dark gray bars) or the inhibitor PHA-408 (20, 10, 5, 2.5 μM light gray bars). Relative mRNA levels of E-selectin were normalized to GAPDH and expression levels are depicted as mean fold change compared to non-stimulated cells. (A) Real-time PCR of IL-1β (5 ng/ml, 90 min) stimulated HUVEC which were either left untreated (CTRL, black bar) or pretreated (30 min) with either 166, 125, 100 μg/ml of comfrey-RE (gray dotted bars) or with 20, 10, 5 μg/ml of comfrey-OP (black dotted bars). officinale root extract preparations affect E-selectin expression in a dose- and time-dependent manner. NF-κB Symphytum officinale comfrey endothelial cells inflammation transactivation transcription. These results provide a first mechanistic insight into the mode of action of a century-old popular herbal medicine. Furthermore, our biochemical studies provide evidence that comfrey inhibits NF-κB signaling at two stages: it dampens not only the activation of IKK1/2 and the subsequent IκBα degradation, but also interferes with NF-κB p65 nucleo-cytoplasmatic shuttling and transactivation. Both preparations inhibit the activation of NF-κB, a transcription factor of central importance for the expression of these and other pro-inflammatory genes. The extract, and especially its mucilage-depleted fraction, impair the interleukin-1 (IL-1) induced expression of pro-inflammatory markers including E-selectin, VCAM1, ICAM1, and COX-2. Here, we show that a hydroalcoholic extract of comfrey root impairs the development of a pro-inflammatory scenario in primary human endothelial cells in a dose-dependent manner. ![]() However, the molecular basis of its action remained elusive. Today, its topical use is based on its analgesic and anti-inflammatory effects, which have been substantiated by modern clinical trials. Symphytum officinale, commonly known as comfrey, constitutes a traditional medicinal plant with a long-standing therapeutic history, and preparations thereof have been widely used for the treatment of painful muscle and joint complaints, wound and bone healing, and inflammation.
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Emergency room scribe jobs near me1/28/2024 ![]() Applicants with questions about access or requiring a reasonable accommodation for any part of the application or hiring process should contact USC Human Resources by phone at (213) 821-8100, or by email at Inquiries will be treated as confidential to the extent permitted by law. We provide reasonable accommodations to applicants and employees with disabilities. USC will consider for employment all qualified applicants with criminal histories in a manner consistent with the requirements of the Los Angeles Fair Chance Initiative for Hiring ordinance (PDF) opens in a new window. News & World Report honor roll hospital in the heart of the Illinois Medical District. Find a Location Near You A A Translate Inova-GoHealth Urgent Care Partnership Save your spot online or walk in 7 days a week Providing Urgent Care in Your Neighborhood Inova-GoHealth Urgent Care Centers provide easy access to high quality urgent care throughout the Northern Virginia community. Were local, so you get the hands-on guidance and access to our leadership for all your training and professional needs. As a scribe, you will have the chance to work side-by-side with healthcare providers, gaining invaluable first-hand experience in the medical field. Medical Scribe - Seattle Scribe.ology 3.8 Seattle, WA 98104 (First Hill area) Madison St & 8th Ave Full-time + 1 Monday to Friday A medical scribe is a trained documentation specialist who charts patient encounters in real-time using the Electronic Health Record. ![]() As a condition to begin employment, all new hires at. Job Description: ScribeAmerica is offering an exciting opportunity to kickstart your career in healthcare by providing unique scribing opportunities in-person and remotely across the United States. Joseph (IN), Elkhart, Marshall, La Porte and St. We provide fast, expert care throughout the region, including St. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other characteristic protected by law or USC policy. At UNC Health, our goal is to protect the health and well-being of North Carolinians and others we serve. Emergency medicine professionals at Memorial Hospital of South Bend, Elkhart General Hospital, Community Hospital of Bremen, Beacon Granger Hospital and Three Rivers Hospital are available 24/7. USC is an equal opportunity, affirmative action employer.
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Installing i5 procssor1/28/2024 With driver backup, you can rollback any driver's software to an earlier version if there is a malfunction. Step 1: Prepare your parts Step 2: Install the CPU Step 3: Install the cooler Step 4: Test it out For starters, the pins are on the chip itself, rather than in the socket. Driver update utilities ensure you have correct drivers that are compatible with your hardware, it also guarantees that there is a backup of current drivers before any software/hardware changes are made. Installing the wrong driver, or simply an incompatible version of the right driver, can make your problems even worse.Īnother significant problem is using a driver upgrade program which is too laborious to do. Power up your productivity, gaming, and content creation experiences by installing the Intel Core i5-11400 2.6 GHz Six-Core LGA 1200 Processor into your. Even seasoned, tech-savvy people with the good habit of updating Core i5 Desktop Processor device drivers, can still find the entire installation and upgrading process time-consuming and annoying. Click for pictures, reviews, and tech specs for the LG gram 14.0 Intel Core i5 processor Lightweight. It is not straightforward to get Core i5 Desktop Processor drivers due to Intel's large and confusing official website. Get more information on the LG 14Z980-G.AA5CA3. The positive aspect is that once you update your Processor's driver it will stop crashing. Drivers will work one day, and for a variety of reasons, suddenly quit working the next day. ![]() Complications of Maintaining DriversĬore i5 Desktop Processor errors can be rooted in an outdated or corrupted device driver. Drivers are mini software programs created by Intel that allow your Core i5 Desktop Processor hardware to communicate effectively with your operating system.
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Jammit app 20171/28/2024 ![]() Line 6 Mobile In is $79.95US (estimated street price) and can be purchased from a variety of retailers. Songs range in price from $1.99 to $5.99US. Jammit is available as a free download from the App Store (opens in new tab). As of this writing, over 300 songs are available for guitar, bass, drums, keyboards and vocals. What used to be complex and costly is now easily accessible to all guitarists - so they can focus on playing instead of on how to get a certain sound."Īmong the 150-plus artists who have licensed tracks to Jammit are Mastodon, Yes, Boston, Steve Vai, Pantera and the Grateful Dead. Line 6 co-founder Marcus Ryle has nothing but raves: "The Jammit app gives guitarists a uniquely inspiring way to do what they've always wanted to do: play their favorite songs with their favorite bands. The minute they start playing around with Jammit, they go, 'This is amazing! How can we get on board?'" "We're signing up so many bands and artists, it's great. "We have specialists for each instrument."Īnd what's been the response from artists? "They love it," says Humphrey. "We do all of our own notation," says Humphrey. A little light bulb went on over my head…"Īlong with the cool track isolating, looping and speed-manipulation functions, Jammit also provides note-for-note transcriptions and tab. But the time I came back, the guitarist would have the part figured out. What I ended up doing was, I'd take a section, loop it, put it on a click track, maybe slow it down and walk out of the room. Sometimes they might not remember how they played certain parts. "I would be sitting with guitar players and we'd be going over demos that were two or three years old. ![]() And once they've got their smoking riffs and solos nailed, they can record them right along with the master.Īccording to record producer and Jammit CEO Scott Humphrey, the idea of the Jammit software came to him while working with artists in the studio. ![]() Players can navigate to whatever section of a song they like, loop and slow it down to as much as half-speed (without changing pitch). With Jammit, musicians are virtually able to become part of Rush, Dream Theater, the Foo Fighters, Nirvana and many, many more, as the software allows them to isolate guitar, bass, drums, keyboard or vocal tracks for intense examination. Released in 2011, Jammit is the revolutionary music software, available for iPad, iPhone, iPod Touch and Mac OS X desktop (a Windows version is coming), that can isolate individual audio tracks within original multi-track master recordings.
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Defcon 2021 date1/27/2024 ![]() The forum highlights a different theme annually, but always through the lens of individual and government security. Positive Hack Days, known as PHDays, is similar to other hacker-focused cybersecurity conferences like Blackhat and DEFCON. Positive Hack Days 12Ĭalling IT and InfoSec pros, no matter your career stop. The location of the event is actually confidential until the week of the conference. That secrecy thing, by the way, is not a gimmick. In fact, this event is so local that it has remained small, non-profit and non-commercial, with rarely more than a couple thousand in attendance. (Check our our complete RSA Guide to see where & how to meet Splunk.)Īnother hacking conference? Not so! This hacking conference is Top Secret and it’s held specifically for the local hacking culture in Chicago. ![]() Like many conferences and events, they’ve also spun up a whole library of live and on-demand security trainings, videos, webinars and more, so check their schedule regularly throughout the year. RSA is committed to sharing a world of diverse knowledge in security, which is why the theme for RSAC 2023 is “Stronger Together”. RSA Conference (aka RSAC) in June 2022 was a great affair, and they’ve already announced the 2023 dates for their marquee event – which you can register interest for now. ![]() Known across the cybersecurity landscape, RSA Conference bills itself as “Where the world talks about security”. ( Know the differences between RBAC & ABAC.) This Gartner event is the leading IAM conference to help you make the right decisions about which identity-first security initiatives to prioritize, how to modernize existing staffing models and whether to invest in new tools to take your organization’s security posture into the identity-first era. Join over 1,500 IAM and security peers over 3 days, with 70+ sessions, 60+ vendors and 30+ IAM analysts. (Bonus: Splunk’s own Ryan Kovar, of SURGe, will be presenting.) Gartner Identity & Access Management Summit 2023 Learn, connect and share with thousands of global participants and walk away with real-world insights that you can put into action soon. InfoSec, Cybersecurity & IT Conferences and Events 2023 SANS Cyber Threat Intelligence Summit 2023įor anyone in cyber threat intelligence (CTI), from newbies to experienced pros, this is the summit to get hands-on education and new perspectives that challenge traditional CTI assumptions. Beyond security, we also cover DevOps Conferences & Events and Blockchain/Web3 Events.) (Check out more recommendations: Security Books & Articles and Security Certifications To Earn. To add to this list, contact the conference/event name, dates, location, website and a quick summary. ![]() Events planned for 2023, but without specific dates yet.These often come with lower price tags and access to knowledge that doesn't require travel.Īnd now, onto the list of security events and conferences! We’ve divided the listings into two categories: The good news is that these events now cater to a wider audience, with many in-person events continuing to offer a virtual or hybrid experience. You can look for conferences that cover a wide variety of topics, or you can opt for a more niche events that cater to specific platforms, technologies or methodologies. So, if you’re a security pro and looking to get back to in-person conferences, we’ve got you covered with this round-up of top security conferences and events for 2023.Īttending conferences is a great way to stay up-to-date with your industry and network and experienced and like-minded professionals. After all, security relies on good data - and today, we have more data than ever. Opportunities to network, learn and see work colleagues that we haven’t seen in person in years.įor security professionals, your role is more visible than it ever has been, with news of cyberattacks and data breaches making headlines on a routine basis. Finally! We’re starting to get back to traveling and gathering again. |